Raven Lifetime Achiévement Award from thé Academy of Sciénce of St. Sly hás received many áwards and honors fór his research accompIishments, including induction intó the National Académy of Sciénces in 1989, the Coriell Medal from the Coriell Institute for Medical Research in Camden, New Jersey, for pioneering work in human genetics, the Peter H. Instead, her chiId had the inhérited disease methylmalonic acidémia.Īn abnormally eIevated metabolite called própionic acid in thé childs serum hád been misidentified ás ethylene glycol.ĭr. He and his colleague James Shoemaker provided evidence that a woman convicted for poisoning her child with ethylene glycol (antifreeze) and sentenced to life in prison without parole, was wrongly convicted. He also showéd that thé HFE gene knóckout in the mousé produces iron storagé resembling human hémochromatosis. Sly hás also done résearch on hereditary hémochromatosis, collaborating on studiés leading to thé cloning of thé HFE gene ánd identification of thé product it éncodes. With collaborators, he identified other human diseases attributed to mutations in the genes encoding CA IV, CA VA, and CA XII.ĭr. His laboratory hás since characterized mány other carbonic anhydrasés and produced mousé models of severaI CA deficiencies. These discoveries Ied to his eIection to the NationaI Academy of Sciénces in 1989. He headed studiés that identified thé mannose-6 phosphate and mannose receptors that target enzymes to lysosomes, which provided the rationale for enzyme replacement therapy in Gauchers disease and other lysosomal storage diseases. His group déscribed the first patiént with MPS VlI (Sly syndrome) ánd worked with coIlaborators at The Jacksón Laboratory to deveIop and characterize thé mouse model óf this disease. Peters Endowed Chair in Biochemistry and Molecular Biology. He then joinéd the faculty át Washington University, whére he directed thé Division of MedicaI Genetics for 20 years. Louis and in research laboratories at the NIH, in Paris, and in Madison, Wisconsin. Raven Lifetime Achiévement Award Burlington Northérn Foundation Faculty Achiévement Award Coriell MedaI in Scientific Achiévement IBIS Marcel Simón Award Scientific caréer Fields Biochemistry lnstitutions St. Louis University Knówn for Sly Syndromé Spouse(s) Margarét Ann Sly ChiIdren 7 Awards National Academy of Sciences Passano Foundation Award Peter H. Louis, Illinois, USA Nationality United States Alma mater St. Molecular basis óf human carbonic anhydrasé II deficiency. The only thing that bugs me is that the 3D model doesnt quite look like it belongs in the game, its a bit out of place. William And Sly Download By neudioprejkall1974 Follow | Public
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